USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P09493 USC-OGP 2-DE database:  P09493 P09493 General information about the entry View entry in simple text format Entry name TPM1_HUMAN Primary accession number P09493 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;. Gene name Name=TPM1 Synonyms=C15orf13, TMSA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1227: pI=4.66; Mw=34859 SPOT OGP-1230: pI=5.28; Mw=34566 SPOT OGP-1237: pI=4.73; Mw=33231 Cross-references UniProtKB/Swiss-Prot P09493; TPM1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TPM1_HUMAN Primary accession number P09493 Secondary accession number(s) B7Z5T7 D9YZV2 D9YZV3 D9YZV8 P09494 P10469 Q6DV89 Q6DV90 Q7Z6L8 Q86W64 Q96IK2 Q9UCI1 Q9UCI2 Q9UCY9 Q9Y427 Sequence was last modified on  November 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 187) Name and origin of the protein Description RecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1; Gene name Name=TPM1 Synonyms=C15orf13, TMSA Encoded on Name=TPM1; Synonyms=C15orf13, TMSA Keywords Acetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Muscle protein; Phosphoprotein; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M19267; AAA36771.1; -; mRNA EMBL M19713; AAA61225.1; -; mRNA EMBL M19714; AAA61226.1; -; mRNA EMBL M19715; AAA61227.1; -; mRNA EMBL AY640414; AAT68294.1; -; mRNA EMBL AY640415; AAT68295.1; -; mRNA EMBL AK299387; BAH13023.1; -; mRNA EMBL AL050179; CAB43309.2; -; mRNA EMBL GU324929; ADL14500.1; -; Genomic_DNA EMBL GU324930; ADL14501.1; -; Genomic_DNA EMBL GU324933; ADL14504.1; -; Genomic_DNA EMBL GU324935; ADL14506.1; -; Genomic_DNA EMBL AC079328; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471082; EAW77619.1; -; Genomic_DNA EMBL CH471082; EAW77622.1; -; Genomic_DNA EMBL CH471082; EAW77623.1; -; Genomic_DNA EMBL CH471082; EAW77627.1; -; Genomic_DNA EMBL CH471082; EAW77628.1; -; Genomic_DNA EMBL BC007433; AAH07433.1; -; mRNA EMBL BC050473; AAH50473.1; -; mRNA EMBL BC053545; AAH53545.1; -; mRNA EMBL X12369; CAA30930.1; -; mRNA CCDS CCDS10181.1; -. [P09493-10]; . CCDS CCDS32262.1; -. [P09493-7]; . CCDS CCDS32263.1; -. [P09493-3]; . CCDS CCDS32264.1; -. [P09493-5]; . CCDS CCDS45273.1; -. [P09493-1]; . CCDS CCDS58368.1; -. [P09493-8]; . CCDS CCDS58369.1; -. [P09493-9]; . PIR A27674; A27674; . PIR A27678; A25825; . PIR S05585; S05585; . RefSeq NP_000357.3; NM_000366.5. [P09493-10]; . RefSeq NP_001018004.1; NM_001018004.1. [P09493-9]; . RefSeq NP_001018005.1; NM_001018005.1. [P09493-1]; . RefSeq NP_001018006.1; NM_001018006.1. [P09493-3]; . RefSeq NP_001018007.1; NM_001018007.1. [P09493-7]; . RefSeq NP_001018008.1; NM_001018008.1. [P09493-5]; . RefSeq NP_001018020.1; NM_001018020.1. [P09493-8]; . RefSeq NP_001288173.1; NM_001301244.1. [P09493-6]; . RefSeq NP_001317273.1; NM_001330344.1; . RefSeq NP_001317275.1; NM_001330346.1; . RefSeq NP_001317280.1; NM_001330351.1; . UniGene Hs.133892; -; . UniGene Hs.602995; -; . ProteinModelPortal P09493; -; . SMR P09493; -; . BioGrid 113021; 126; . IntAct P09493; 37; . MINT MINT-1458755; -; . iPTMnet P09493; -; . PhosphoSitePlus P09493; -; . SwissPalm P09493; -; . BioMuta TPM1; -; . DMDM 136092; -; . UCD-2DPAGE P09493; -; . EPD P09493; -; . MaxQB P09493; -; . PeptideAtlas P09493; -; . PRIDE P09493; -; . DNASU 7168; -; . Ensembl ENST00000267996; ENSP00000267996; ENSG00000140416. [P09493-7]; . Ensembl ENST00000288398; ENSP00000288398; ENSG00000140416. [P09493-10]; . Ensembl ENST00000334895; ENSP00000334624; ENSG00000140416. [P09493-5]; . Ensembl ENST00000358278; ENSP00000351022; ENSG00000140416. [P09493-3]; . Ensembl ENST00000403994; ENSP00000385107; ENSG00000140416. [P09493-1]; . Ensembl ENST00000559397; ENSP00000452879; ENSG00000140416. [P09493-8]; . Ensembl ENST00000559556; ENSP00000453941; ENSG00000140416. [P09493-9]; . GeneID 7168; -; . KEGG hsa:7168; -; . UCSC uc002alg.4; human. [P09493-1]; . CTD 7168; -; . DisGeNET 7168; -; . GeneCards TPM1; -; . GeneReviews TPM1; -; . HGNC HGNC:12010; TPM1; . HPA CAB017698; -; . HPA HPA000261; -; . HPA HPA047089; -; . HPA HPA053624; -; . MalaCards TPM1; -; . MIM 115196; phenotype; . MIM 191010; gene; . MIM 611878; phenotype; . neXtProt NX_P09493; -; . OpenTargets ENSG00000140416; -; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 155; Familial isolated hypertrophic cardiomyopathy; . Orphanet 54260; Left ventricular noncompaction; . PharmGKB PA36690; -; . GeneTree ENSGT00550000074494; -; . HOGENOM HOG000231521; -; . HOVERGEN HBG107404; -; . InParanoid P09493; -; . KO K10373; -; . PhylomeDB P09493; -; . TreeFam TF351519; -; . Reactome R-HSA-390522; Striated Muscle Contraction; . Reactome R-HSA-445355; Smooth Muscle Contraction; . ChiTaRS TPM1; human; . GeneWiki TPM1; -; . GenomeRNAi 7168; -; . PRO PR:P09493; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000140416; -; . ExpressionAtlas P09493; baseline and differential; . Genevisible P09493; HS; . GO GO:0015629; C:actin cytoskeleton; IDA:HPA; . GO GO:0005884; C:actin filament; IBA:GO_Central; . GO GO:0032059; C:bleb; IMP:BHF-UCL; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0031941; C:filamentous actin; IEA:Ensembl; . GO GO:0005862; C:muscle thin filament tropomyosin; TAS:ProtInc; . GO GO:0032587; C:ruffle membrane; IDA:BHF-UCL; . GO GO:0030017; C:sarcomere; TAS:BHF-UCL; . GO GO:0001725; C:stress fiber; IDA:BHF-UCL; . GO GO:0003779; F:actin binding; TAS:BHF-UCL; . GO GO:0051015; F:actin filament binding; IBA:GO_Central; . GO GO:0008092; F:cytoskeletal protein binding; IPI:UniProtKB; . GO GO:0005200; F:structural constituent of cytoskeleton; TAS:BHF-UCL; . GO GO:0008307; F:structural constituent of muscle; TAS:ProtInc; . GO GO:0007015; P:actin filament organization; IBA:GO_Central; . GO GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL; . GO GO:0034614; P:cellular response to reactive oxygen species; IEP:BHF-UCL; . GO GO:0007010; P:cytoskeleton organization; TAS:BHF-UCL; . GO GO:0001701; P:in utero embryonic development; IEA:Ensembl; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0006936; P:muscle contraction; TAS:Reactome; . GO GO:0030049; P:muscle filament sliding; ISS:BHF-UCL; . GO GO:0030336; P:negative regulation of cell migration; ISS:BHF-UCL; . GO GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IMP:BHF-UCL; . GO GO:1904706; P:negative regulation of vascular smooth muscle cell proliferation; IMP:BHF-UCL; . GO GO:0032781; P:positive regulation of ATPase activity; ISS:BHF-UCL; . GO GO:0045785; P:positive regulation of cell adhesion; ISS:BHF-UCL; . GO GO:0003065; P:positive regulation of heart rate by epinephrine; ISS:BHF-UCL; . GO GO:0051496; P:positive regulation of stress fiber assembly; ISS:BHF-UCL; . GO GO:0008360; P:regulation of cell shape; IMP:BHF-UCL; . GO GO:0008016; P:regulation of heart contraction; TAS:ProtInc; . GO GO:0006937; P:regulation of muscle contraction; TAS:ProtInc; . GO GO:0031529; P:ruffle organization; ISS:BHF-UCL; . GO GO:0045214; P:sarcomere organization; IMP:BHF-UCL; . GO GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL; . GO GO:0042060; P:wound healing; ISS:BHF-UCL; . InterPro IPR000533; Tropomyosin; . Pfam PF00261; Tropomyosin; 1; . PRINTS PR00194; TROPOMYOSIN; . PROSITE PS00326; TROPOMYOSIN; 1; .

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